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Trazodone is a prescription medication primarily used to treat major depressive disorder (MDD) and insomnia. It belongs to a class of medications known as serotonin antagonist and reuptake inhibitors (SARIs), although its exact mechanism of action is not fully understood.

In the treatment of depression, trazodone works by increasing the levels of serotonin in the brain, which is thought to help regulate mood. It may also have some antagonist activity at certain serotonin receptors. Trazodone is often prescribed off-label for other conditions, such as anxiety disorders, post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD).

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